It then goes on to the town of Kershaw, running concurrent with US 601. It passes under I-20 and proceeds to Camden. Leaving Sumter, US 521 is known as Camden Highway. In Sumter, it runs together with US Business 378. It crosses over I-95 and heads to the city of Sumter. In Manning SC 261 branches off and US 521 merges with US 301 for a short distance. There is a brief section right before Manning where it runs concurrent with SC 261. From here to the city of Manning it is known as the Greeleyville Highway. Starting at the city of Georgetown, US 521 runs through the town Andrews to Greeleyville.
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